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"Greatness in life lies in the magnitude of the dream you choose to believe in"
Martin Luther King

A light at the end of the tunnel. Is it possible to cure MS?

A Guide on AHSCT for MS

No miracle claims, just scientific facts

CUREMS - Source pexels by kasuma

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🔔 Last update on January 22, 2025

“Welcome to CureMS,

I’ve created this non-profit website with the aim of expanding information regarding therapies and procedures that could lead to the curing of MS. Specifically, the site is dedicated to autologous hematopoietic stem cell transplantation (AHSCT), because it is the procedure that may today, in some patients, approach a cure for MS.

While MS is generally considered incurable, clinical data shows that some patients achieve long-term remission without medications post-transplant.

On CureMS, you won’t find miraculous recipes or simple solutions to a complex problem like MS, and it does not intend to fuel unfounded hopes or illusions.

The information on this site has been previously published in scientific journals, which use the “peer review” method, meaning each article is subject to evaluation by other scientists and is published only if it passes their scrutiny (Evidence-Based Research).

CureMS website is funded through donations to the non-profit organization Fondazione per la Ricerca Biomedica (FORB) ONLUS”.

Antonio Bertolotto, Neurologist

What is AHSCT?

AHSCT is a one-off treatment that involves a complex, multistep procedure aimed at resetting the immune system, which mistakenly attacks the Central Nervous System in pwMS (person with Multiple Sclerosis). First, your own hematopoietic stem cells are collected from your blood. Then, chemotherapy is used to wipe out the malfunctioning immune system by destroying certain types of cells. Finally, your stem cells are reinfused to help regenerate a healthier immune system.

Like any procedures, drugs, or therapies, AHSCT offers both benefits and associated side effects and risks.

Analysis of the results shows that no treatment, in any study, has been proven to be more effective—radiologically, clinically, or immunologically—than AHSCT (i.e., transplant).

Discover AHSCT

Explore AHSCT in this brief video: learn how the procedure works and how it resets the immune system.

News on Curems.net

We’ve added a short video of the AHSCT procedure for MS.

Learn more

New Study Reveals That AHSCT Normalizes Micro-RNA Expression Levels, Suggesting a Potent Treatment Effect.

Refractory Autoimmune Retinopathy: A Case Successfully Treated with AHSCT

Learn more

What You’ll Find In This Website

Mission

Our mission is to help patients and healthcare providers make informed decisions about AHSCT; make scientific evidence understandable to the general population; present scientific facts…

Why a Website About AHSCT?

We have chosen to dedicate this website mainly to AHSCT because this topic is only marginally addressed in both the scientific literature and in scientific meetings.

Working Definition of Cure

If we assume that it is possible to “cure” MS, what clinical, radiological, and biological characteristics must a person with MS have to be defined as “cured”? And how long must he/she remain in such a condition? How should the therapy capable of curing MS act?

Types of MS and AHSCT

The course of MS is classically subdivided in 3 forms: RRMS, SPMS and PPMS. Here, we provide a summary of key guidelines and recommendations from scientific societies, along with expert position papers.

Benefits of AHSCT

The analysis shows that no treatment, in any study, has been proven more effective than AHSCT in radiological, clinical, or immunological outcomes. In this section, you will find clinical data from trials and studies on transplantation in pwMS.

Risks of AHSCT

The greatest concern with AHSCT is the risk of transplant-related mortality (TRM), but this has been reduced with increasing experience, selection of less disabled patients, and supportive care improvements.

For simplicity, the terms “AHSCT” and “transplant” are used interchangeably on this site.

You can enlarge all the figures by simply clicking on them.

We have included numerous acronyms that are available in popovers. Just hover the mouse over them to read them.

All references are underlined and linked. Click on them for further reading.

This website provides general information and is NOT a substitute for professional medical advice. Read the disclaimers at the end of this page.

AHSCT is a complex topic. We are doing our best to keep this website updated. All suggestions to improve our website are welcome. Contact us at info@curems.net or click the button below

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